Our thesis is that fusion/registration of magnetic resonance and ultrasound information can make significant contributions to the initial diagnosis and localisation of prostate cancer, and as such to the staging process (surgery/radiotherapy). In addition, the available information can be used to improve localisation of biopsies and therapy (both the targeting of specific areas and the monitoring of treatment). Current approaches to the fusion of MRI and ultrasound prostate information tend to rely on manual intervention or tracking systems. We propose to develop a data driven approach to this fusion/registration problem, which will use prostate boundary and internal anatomical region information. The automatic segmentation of these prostate features will be based on shape and texture analysis techniques. The resulting fusion of MRI and ultrasound data will form the basis for the clinical evaluation with respect to the diagnosis and localisation of prostate cancer